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Some related publications:
2. Mathematical analysis and optimal control study of cholera dynamics. Cholera is a severe water-borne infectious disease caused by the bacterium Vibrio cholerae. Recent cholera outbreaks in Haiti (2010-2011), Nigeria (2010), Kenya (2010), Vietnam (2009), Zimbabwe (2008-2009), etc., continue leading to a large number of infections and deaths, and receiving worldwide attention. The dynamics of cholera are complicated by the multiple transmission pathways which involve both direct human-to-human and indirect environment-to-human modes, and by the different factors in pathogen ecology. Due to the coupling between human populations and environmental components, mathematical epidemiological models for cholera generally constitute high-dimensional nonlinear ODE systems for which the classical Poincare-Bendixson theory is no longer valid. In collaboration with Z. Mukandavire, J.P. Tian, S. Liao (my former student) and others, I have conducted a careful analysis on the epidemic and endemic dynamics of cholera epidemiological models, and validated the analytical predictions through realistic case studies. Meanwhile, I work with H. Gaff, E. Schaefer, R. Fister and S. Lenhart on optimal controls of cholera. We use optimal control theory to seek cost-effective balance of different intervention strategies against cholera outbreaks.
Some related publications:
3. Numerical study of fluid-structure interactions. In fluid-structure interaction (FSI) problems, one or more solid structures interact with an internal or surrounding fluid flow. FSI problems play prominent roles in many scientific and engineering fields, yet a comprehensive study of such problems remains a challenge due to the strong nonlinearity and multi-physics involved. For most FSI problems, analytical solutions to the model equations are impossible to obtain, whereas laboratory experiments are limited in scope; thus numerical simulation offers a powerful means to investigate the fundamental physics involved in the complex interaction between fluids and solids. Working with A. Layton, G. Hou, L. Zhang, J. Gounley (my student), C. Modnak (my student) and other collaborators, I am developing accurate and efficient numerical algorithms for FSI simulation, with application to particle sedimentation and aggregation, wave energy dynamics, high-performance marine crafts, etc. I am currently exploring sharp-interface computational techniques to improve the classical immersed boundary method, and re-formulation of FSI problems into constrained dynamical systems which can be solved by fast iterative algorithms.
Some related publications:
4. Modeling and computation of tumor growth. Cancer is a leading cause of death in developed countries, killing millions of people every year. Despite major medical and technological advances in recent years and tremendous efforts devoted to tumor research, diagnosis and treatment, a cure for cancer remains elusive. Mathematical models and computational methods provide an important way to investigate tumor growth and improve our understanding of the fundamental mechanism. In collaboration with J.P. Tian, A. Friedman, E. Chiocca and other colleagues, we have developed new models for tumor evolution based on reaction-diffusion equations, and carefully analyzed various treatments on brain tumors including resection, virotherapy, radiotherapy and chemotherapy. Results from our model simulation have been validated by experimental measurements. We are currently exploring a multi-scale multi-physics simulation approach to better understand the highly complex process of tumor growth, especially the early stage tumor formation and development.
Some related publications:
A list of all my journal publications can be found here.
I gratefully acknowledge grant supports from:
Teaching
In addition, here are the links for some classes I taught years ago.
At Duke:
At Ohio State: