Numerical simulations for electrically induced, intra-cellular calcium-release from the endoplasmic reticulum are reported. A two-step model is used for self-consistency. Distributed electrical circuit representation coupled with the Smoluchowski equation yields the Endoplasmic Reticulum (ER)  membrane nano-poration dynamics. This is combined with the continuum Li-Rinzel model for calcium flow. Our results are shown to be in agreement with reported calcium release data. A modest increase (rough doubling) of the cellular calcium is predicted in the absence of extra-cellular calcium. In particular, the applied field of 15 kV/cm with 60 ns pulse duration makes for a strong comparison. No oscillations are predicted and the net recovery period of about 5 minutes, are both in agreement with published experimental results.

Simulation results for average Ca-concentration in the ER as a function of time.

Simulation results for average Ca-concentration in cytosol as a function of time.